I had nail problems from my chemo (the taxane group is one culprit). My nails became loose. After chemo, I lost both of my big toenails, which did grow back. All of my toenails have become thickened and changed shape. I visited a Podiatrist, Brooks Young (he is great, BTW) who told me he has researched these issues in the literature since his mom also has issues from her breast cancer. He explained the importance of using Vicks Vaporub on them nightly, rubbed into the nails nd nail beds.